Table 2.

Functional groups predicted to be affected during EAE in caudal NPCs^a

Functions annotation	p value	Prediction	z-score	No. of molecules
Formation of cellular protrusions	8.38E-10	Decreased	−3.34	124
Growth of neurites	3.87E-08	Decreased	−2.88	77
Morphogenesis of neurites	4.23E-05	Decreased	−2.33	51
Branching of neurites	2.18E-04	Decreased	−2.22	34
Dendritic growth/branching	7.32E-04	Decreased	−2.19	25
Neuritogenesis	3.27E-06	Decreased	−2.09	75
Differentiation of cells	1.70E-10	Decreased	−3.22	287
Inflammation of organ	6.10E-04	Increased	4.20	108
Synthesis of lipid	2.04E-05	Decreased	−2.49	104
Synthesis of phospholipid	2.54E-04	Decreased	−2.27	30
Metabolism of membrane lipid derivative	9.81E-06	Decreased	−2.24	63
Neurodegeneration	2.35E-07	Increased	2.28	41
Degeneration of axons	4.74E-05	Increased	2.55	15
Degeneration of neurites	2.99E-05	Increased	2.72	16
Apoptosis of neurons	4.23E-05	Increased	4.02	59
Cell survival	1.00E-07	Decreased	−5.43	185
Quantity of cells	9.97E-11	Decreased	−5.09	259
Cell viability	1.10E-06	Decreased	−5.05	168

^aEAE-regulated genes in the caudal NPCs were annotated to functional clusters using IPA. Here we show the functional groups (column 1) that have the strongest prediction rates to be either decreased or increased during EAE. The prediction rate is defined by the z-score, and the predictions with a z-score >2 or <−2 were deemed significant. A negative z-score shows a down-regulated function, whereas a positive z-score shows an up-regulated function. The last column shows the number of molecules annotated to a certain function.