Table 3.
Functional groups belonging to the Nervous System Development and Function category that were affected in caudal NPCs from EAEa
| Functions annotation | p value | Activation | Activation z-score | No. of molecules |
|---|---|---|---|---|
| Myelination | 6.59E-10 | 0.003 | 47 | |
| Growth of neurites | 1.28E-05 | Decreased | −2.875 | 77 |
| Morphology of nervous system | 1.28E-05 | 134 | ||
| Outgrowth of neurites | 3.78E-05 | Decreased | −2.558 | 68 |
| Regeneration of neurites | 1.48E-04 | −0.047 | 15 | |
| Quantity of neuroglia | 1.80E-04 | −0.213 | 22 | |
| Neuritogenesis | 4.13E-04 | Decreased | −2.088 | 75 |
| Quantity of Schwann cells | 5.48E-04 | −1.53 | 7 | |
| Morphology of nervous tissue | 6.18E-04 | 92 | ||
| Development of CNS | 6.39E-04 | −1.452 | 96 | |
| Regeneration of axons | 1.37E-03 | 0.095 | 12 | |
| Myelination of cells | 1.46E-03 | 17 | ||
| Accumulation of neuroglia | 2.09E-03 | 0 | 5 | |
| Quantity of CNS cells | 2.27E-03 | −0.894 | 27 | |
| Morphogenesis of neurites | 2.48E-03 | Decreased | −2.326 | 51 |
| Proliferation of neuroglia | 3.63E-03 | −0.176 | 23 | |
| Morphology of CNS | 4.39E-03 | 80 | ||
| Length of neurites | 4.63E-03 | Decreased | −2.243 | 15 |
| Proliferation of neuroblasts | 5.72E-03 | −0.915 | 17 | |
| Abnormal morphology of PNS glial cells | 5.95E-03 | 8 | ||
| Abnormal morphology of neuroglia | 6.27E-03 | 19 | ||
| Abnormal morphology of oligodendrocytes | 7.09E-03 | 6 | ||
| Branching of neurites | 8.59E-03 | Decreased | −2.223 | 34 |
| Axonogenesis | 9.14E-03 | −0.036 | 32 | |
| Quantity of cholinergic neurons | 9.90E-03 | −0.896 | 5 | |
| Regeneration of nervous tissue | 9.90E-03 | −0.728 | 7 | |
| Morphology of axons | 9.90E-03 | 18 | ||
| Differentiation of neurosphere cells | 1.09E-02 | −0.438 | 6 | |
| Growth of axons | 1.31E-02 | −0.172 | 24 | |
| Auditory evoked potential | 1.35E-02 | Decreased | −2.485 | 16 |
| Morphology of neuroglia | 1.43E-02 | 22 | ||
| Motor function | 1.54E-02 | −1.332 | 19 | |
| Morphology of brain | 1.64E-02 | 70 | ||
| Differentiation of neuroblasts | 1.79E-02 | −0.936 | 7 | |
| Survival of oligodendrocytes | 1.79E-02 | −0.068 | 7 | |
| Abnormal morphology of Schwann cells | 1.79E-02 | 7 | ||
| Abnormal morphology of sciatic nerve | 1.79E-02 | 7 | ||
| Development of brain | 1.89E-02 | −0.998 | 68 | |
| Abnormal morphology of axons | 1.89E-02 | 17 | ||
| Dendritic growth/branching | 1.95E-02 | Decreased | −2.188 | 25 |
| Function of excitatory synapses | 1.95E-02 | 3 |
aGenes in caudal NPCs that were EAE-regulated and belonged to the Nervous System Development and Function category were annotated to functional groups using IPA. Here we show the functional groups (column 1) that have the strongest prediction rates to be either decreased or increased during EAE. The prediction rate is defined by the z-score, and the predictions with a z-score >2 or <−2 were deemed significant. A negative z-score shows a down-regulated function, whereas a positive z-score shows an up-regulated function. The last column shows the number of molecules annotated to a certain function.