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. 2014 Oct 29;34(44):14739–14751. doi: 10.1523/JNEUROSCI.0860-14.2014

Figure 5.

Figure 5.

Local injection of recombinant BDNF protein into the cingulate cortex induced sustained cold hypersensitivity. A–C, Behavioral studies indicate that rBDNF injection into ACC induced a significant cold allodynia (A) and a cold hyperalgesia (B) that was maintained for (at least) 13 d postinjection, but no modification of mechanical sensitivity (C); N = 7 GFP, n = 6 rBDNF, two-way ANOVA followed by a Student-Newman–Keuls post hoc test; A: F(1,85) = 53.318, p < 0.001; B: F(1,85) = 44.451, p < 0.001; C: F(1,85) = 1.167, p = 0.282; *p < 0.05, **p < 0.01, ***p < 0.001 versus control rats; #p < 0.05, ###p < 0.001 comparison between different time points.