Figure 5.

Disrupting kisspeptin-Gpr54 signaling at the GnRH neuron blunts the neonatal testosterone surge. Quantitative analysis (mean ± SEM) of the level of plasma testosterone 1–2 h after birth in male and female wild-type and GnRH-Gpr54KO mice (n = 8–18/sex/genotype). Groups were compared using a two-way ANOVA with post hoc Student–Newman–Keuls pairwise comparisons; sex p < 0.001, genotype p = 0.05. Bars labeled with different letters are significantly different from each other at either p < 0.01 or p < 0.001 (see text).