Figure 11.

FE91 validation analysis. Figure summarizes findings of the validation analysis using the Felleman and Van Essen (1991) FE91 atlas. A, The 78 regions of the FE91 atlas (Felleman and Van Essen, 1991), color coded according to their anatomical modular structure (five main modules, color coded in blue, purple, orange, yellow, and green; and subclusters of the two-step module depicted in color shades). B, Map of the degree distribution across the FE91 regions. C, Two distribution maps of pyramidal complexity values as collated from the Elston papers, showing a map of dendritic tree size (left) and spine count (right). D, Distribution map of neuronal count as mapped by Collins et al. (2010). Consistent with the main analysis based on the WBB47 atlas (e.g., Fig. 4), analysis of the FE91 dataset revealed several associations between macroscale network organization and microscale neuroarchitectonics. E, Summary of three of these associations, showing a significant positive relationship between macroscale degree and dendritic tree size, spine count, and the ratio between total cell count and total neuronal count (surviving partial Bonferroni correction). F, Distribution of high-degree rich club nodes across the cortex as observed in the FE91 dataset (left). Consistent with the main analysis (Fig. 10), rich club nodes were observed to show a significantly larger dendritic tree size and higher spine count compared with the class of peripheral nodes. *p < 0.05 (surviving partial Bonferroni correction).