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. 2014 Dec 3;34(49):16309–16319. doi: 10.1523/JNEUROSCI.4622-13.2014

Figure 2.

Figure 2.

Representative examples of pulsatile GH secretion profiles (2 animals; #1, closed circles; #2, open circles; A–D, left) and corresponding output figures (A–D, right) in male adult Npy−/− mice (red) and age-matched wild-type littermates (black). Assessment of pulsatile GH secretion was done in ad libitum-fed mice (A, B) and during the first 6 h of fasting (C, D). Samples were collected for 6 h at 10 min intervals, starting at 0700 h (fed) and 1830 h (fasting). Corresponding output figures illustrate the onset of GH pulses (pulse onset indicated by open circles along the x-axis). GH secretory parameters following deconvolution analysis are illustrated in E–H (ad libitum fed) and I–L (fasting). Total (E) and pulsatile GH secretion rate (F), the mass of GH secreted per burst (G), and number of secretory bursts (H) in Npy−/− mice were comparable to ad libitum-fed wild-type mice. In contrast, the fasting-induced suppression of GH secretion observed in wild-type mice was prevented in Npy−/− mice. This was characterized by a significant increase in total (I) and pulsatile GH secretion rate (J), and the mass of GH secreted per burst (K) in Npy−/− mice. The number of secretory bursts (L) remained unchanged. Data are presented as mean ± SEM, N = 10–12, *p < 0.05.