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. 2014 Dec 10;34(50):16784–16795. doi: 10.1523/JNEUROSCI.1867-14.2014

Figure 7.

Figure 7.

CTLs require antigen-dependent activation for neurotoxicity. A, Infarct volume of lymphocyte-deficient Rag1−/− mice receiving 6 × 106 CD8+ T cells from WT or from Rag1 knock-out/OT-I mice (n = 10 per group; *p < 0.05). Whiskers show the 5th to 95th percentiles. Same data are expressed left to the respective whisker in scatter dot plots with mean. B, Flow cytometric representative dot plots (on the left) and quantitative analysis of absolute cell counts of brain-invading CTLs 7 d after MCAO in WT mice and in Rag1−/− mice receiving 6 × 106 CD8+ T cells from WT, Prf1−/−, or OT-I donor animals (n = 5 per group; *p < 0.05). C, D, Flow cytometric representative dot plots (on the left) and quantitative analysis of CD44 (C) and CD62L (D) expression (MFI, mean fluorescent intensity) of brain-invading CD8+ T cells 7 d after MCAO in WT mice and Rag1−/− mice receiving 6 × 106 CD8+ T cells from WT, Prf1−/−, or OT-I donor animals (n = 5 per group; *p < 0.05).