Figure 7.

Significant phase-amplitude coupling with respect to baseline. A, Same-site coupling using up-centered epochs based on the central seed electrode. Left, Heat map indicating number of channels showing reliable same-site coupling at every frequency–frequency bin. Beta and high gamma activity is prominently modulated by spindle phases in the 10–16 Hz range on numerous channels, whereas power in the 30–80 Hz range was affected only by the phase of lower-frequency spindles. Right, Strength of coupling (Z-transformed MI) for example channel indicated in left panel. Black lines indicate extent of significance. B, Similar to A, only for intersite coupling, using down-centered epochs based on the posterior seed.