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. 2014 Feb 19;34(8):2884–2897. doi: 10.1523/JNEUROSCI.1675-13.2014

Figure 4.

Figure 4.

Comparison of the SEC fractionated synthetic Aβ oligomers by ELISA shows 19.3/82E1 ELISA detects HMW Aβ species. Aβ oligomer preps were fractionated by SEC and the fractions tested in a 6E10/12F4, 6E10/6E10, or 19.3/82E1 ELISA. A, The 6E10/12F4 Aβ42 ELISA shows binding to LMW (fractions 28–32) and HMW (fractions 16.5–20.5) Aβ species. B, The 6E10/6E10 ELISA recognized HMW Aβ (fractions 17–21) with no reactivity to LMW Aβ. C, The 19.3/82E1 ELISA also shows selectivity toward HMW Aβ, but recognizes a broader range and higher concentration of Aβ species than 6E10/6E10.