Table 1.
Summary of proteomic changes in Rh1P37H and Rh1WT-expressing retinas, at P2 and P14
| P2-upregulated pathways in Rh1P37H | p value | Ratio | Proteins |
|---|---|---|---|
| Glycolysis | 3.7E-11 | 11/130 (0.085) | PGK1, ALDH2, ACSL3, ENO1, DLAT, PGAM1, ACSS2, ALDH3B1, PFKP, ALDH7A1, DHRS4 |
| Mitochondrial function | 2.6E-10 | 12/174 (0.069) | NDUFS1, NDUFV2, COX6A1, NDUFS8, PARK7, GPD2, XDH, NDUFS2, NDUFB8, OGDH, NDUFB10, NDUFS4 |
| Oxidative phosphorylation | 6.0E-10 | 12/159 (0.075) | ATP6V1E1, ND1, NDUFS1, ATP5H, ATP5O, NDUFV2, COX6A1, NDUFS8, NDUFS2, NDUFB8, NDUFB10, NDUFS4 |
| Ubiquinone biosynthesis | 4.4E-08 | 8/114 (0.07) | ND1, NDUFS1, NDUFV2, NDUFS8, NDUFS2, NDUFB8, NDUFB10, NDUFS4 |
| Citrate cycle | 5.8E-08 | 6/57 (0.105) | CS, IDH3G, ACO2, PCK1, IDH3A, OGDH |
| P2-downregulated pathways in Rh1P37H | p value | Ratio | Proteins |
| EIF2 signaling | 1.57E-06 | 10/202 (0.05) | EIF2S3, RPS3A, EIF3H, EIF1, EIF3A, EIF4A2, EIF4G1, RPLP0, RPS23, RPL38 |
| Regulation of eIF4 and p70S6K signaling | 1.67E-05 | 8/174 (0.046) | EIF2S3, RPS3A, EIF3H, EIF1, EIF3A, EIF4A2, EIF4G1, RPS23 |
| Protein ubiquitination pathway | 1.46E-04 | 9/268 (0.034) | PSMB7, USP7, PSMD11, PSMD7, UBE4B, PSMC6, PSMD14, PSMD4, PSMC3 |
| Purine metabolism | 1.22E-03 | 8/402 (0.02) | DLG1, GMPS, GDA, PSMC6, IMPDH1, CLPX, MYH7, NT5C2 |
| Serotonin receptor signaling | 2.00E-03 | 3/46 (0.065) | GCH1, PTS, DDC |
| P14-upregulated pathways in Rh1P37H | p value | Ratio | Proteins |
| EIF2 signaling | 1.4E-05 | 9/202 (0.045) | RPS20, RPS16, RPS18, EIF1, RPLP2, RPS25, EIF4G1, RPL10A, RPSA |
| mTOR signaling | 1.1E-04 | 8/209 (0.038) | RPS20, RHOC, RPS16, RPS18, RPS25, EIF4G1, RPSA, PRKCA |
| Regulation of eIF4 and p70S6K signaling | 1.4E-04 | 7/174 (0.04) | RPS20, RPS16, RPS18, EIF1, RPS25, EIF4G1, RPSA |
| Caveolar-mediated endocytosis signaling | 2.6E-04 | 5/85 (0.059) | ARCN1, ITSN1, COPA, ACTG2, PRKCA |
| NRF2-mediated oxidative stress response | 4.7E-04 | 7/191 (0.037) | GSTT1, USP14, ABCC1, CAT, VCP, ACTG2, PRKCA |
| P14-downregulated pathways in Rh1P37H | p value | Ratio | Proteins |
| Glutamate metabolism | 1.06E-08 | 6/77 (0.078) | GLUD1, GOT1, GPT2, QARS, GSS, GSTO1 |
| Phe-Ala, Tyr, and Trp biosynthesis | 4.22E-05 | 3/67 (0.045) | GOT1, FARSB, FARSA |
| Glycerophospholipid metabolism | 1.92E-04 | 5/192 (0.026) | DGKZ, PLCB4, GPD1, GNAQ, GOT1 |
| Aminoacyl-tRNA biosynthesis | 3.23E-04 | 3/76 (0.039) | QARS, FARSB, FARSA |
| Mitochondrial dysfunction | 2.11E-03 | 4/174 (0.023) | SDHB, ATP5A1, UQCRC2, UQCRFS1 |