Table 2.

Voxel-based analysis of CB₁R changes in healthy subjects after acute alcohol administration and in alcoholic patients after chronic heavy drinking and abstinence

Cluster level		Voxel level		Peak voxel MNI coordinates			Intensity difference (%)	Cluster location
pcor	kEXT	pFWE	T	x	y	z
ALC ACU > baselinea
0.004	901	0.001	7.37	50	−52	2	+12.1	Inferior temporal gyrus (fusiform gyrus), BA 37
		0.002	6.53	48	−46	6	+6.6	Middle temporal gyrus, BA 21
		0.004	6.28	52	−44	−12	+10.4	Inferior temporal gyrus, BA 20
		0.005	6.09	50	−40	32	+12.9	Inferior parietal lobule (supramarginal gyrus), BA 40
		0.007	5.87	50	−46	20	+11.6	Transverse temporal gyrus, BA 41
		0.015	5.45	46	−38	10	+9.5	Transverse temporal gyrus, BA 41
		0.019	5.33	70	−44	2	+13.3	Middle temporal gyrus, BA 21
		0.023	5.22	68	−48	12	+12.9	Middle temporal gyrus, BA 21
		0.030	5.05	48	−26	−22	+13.9	Inferior temporal gyrus, BA 20
		0.049	4.78	64	−54	20	+10.6	Middle temporal gyrus, BA 21
0.016	272	0.002	6.54	40	−62	26	+9.1	Inferior parietal lobule (angular gyrus), BA 39
CHR patients < healthy controlsb
0.033	4282	0.010	4.38	50	−52	−34	−25.9	Cerebellum crus I
		0.015	4.24	52	−56	−32	−25.1	Cerebellum crus I
		0.020	4.13	48	−64	−30	−24.6	Cerebellum crus I
		0.020	4.12	44	−50	−44	−24.1	Cerebellum crus II
		0.032	3.94	4	−80	−20	−23.2	Lateral occipital gyrus, BA 18
0.047	2795	0.045	3.80	42	−44	56	−25.9	Inferior parietal lobule, BA 40
		0.048	3.54	38	−42	58	−25.3	Somatosensory cortex, BA 2
		0.050	3.75	−12	−82	38	−24.0	Lateral occipital gyrus, BA 19
		< 0.001	3.67	28	−82	32	−23.4	Lateral occipital gyrus, BA 19
		< 0.001	3.66	28	−66	56	−22.4	Superior parietal lobule, BA 7
		< 0.001	3.58	−36	−52	54	−24.3	Inferior parietal lobule, BA 40
ABST patients < healthy controlsc
<0.001	22958	0.012	4.65	−10	10	10	−21.6	Caudate nucleus
		0.014	4.61	48	−64	−30	−23.4	Cerebellum crus I
		0.015	4.56	−2	−82	36	−24.0	Lateral occipital gyrus, BA 19
		0.016	4.55	22	−82	−36	−20.9	Cerebellum crus II
		0.017	4.51	50	−58	−32	−24.0	Cerebellum crus I
		0.021	4.43	4	−78	−22	−23.0	Cerebellar vermis
		0.021	4.42	−8	10	6	−21.7	Caudate nucleus
		0.022	4.42	−12	2	12	−20.3	Caudate nucleus
		0.025	4.36	10	12	2	−22.6	Nucleus accumbens
		0.034	4.23	18	−36	−4	−20.6	Parahippocampal gyrus
		0.035	4.22	32	20	−26	−17.8	Superior temporal gyrus, BA 38
		0.036	4.20	6	12	−2	−21.5	Nucleus accumbens
		0.038	4.18	30	2	−24	−18.5	Amygdala extending to parahippocampal gyrus
		0.038	4.18	14	8	8	−20.4	Caudate nucleus
		0.039	4.17	2	16	−4	−20.4	Subgenual anterior cingulate cortex, BA 25
		0.042	4.14	50	−4	26	−19.3	Precentral gyrus, BA 4
		0.043	4.12	54	4	30	−19.9	Precentral gyrus, BA 4
		0.044	4.11	8	16	−2	−21.3	Nucleus accumbens
		0.045	4.11	38	−22	−16	−19.2	Hippocampus extending to parahippocampal gyrus
		0.045	4.11	40	−48	58	−23.7	Inferior parietal lobule, BA 40
		0.047	4.09	50	−26	26	−18.8	Insula
		0.047	4.09	−46	−16	−18	−19.0	Inferior temporal gyrus, BA 20
		0.048	4.08	−2	14	−2	−20.6	Caudate nucleus

CHR, alcoholics, chronic condition; ABST, alcoholics, abstinence condition; ALC ACU, acute alcohol condition; p_cor, corrected p value; k_EXT, cluster size extent (number of voxels); p_height, significant p threshold; FWE, familywise error (=peak height corrected for multiple voxel comparisons); T, peak voxel t statistic.

^aSignificant clusters obtained at a voxel-level p_height < 0.001 corrected with a cluster-level p_cluster < 0.05 corrected and a cluster threshold of 200 voxels.

^bSignificant clusters obtained at a voxel-level p_height < 0.001 uncorrected with a cluster-level p_cluster < 0.05 corrected and a cluster threshold of 200 voxel.