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. 2014 Feb 5;34(6):2355–2364. doi: 10.1523/JNEUROSCI.4064-13.2014

Figure 3.

Figure 3.

PF-LTP requires 2-AG production and CB1R activation. A, Example PF-EPSCs from WT cells that were stimulated for 5 min at 1 Hz. Cells were filled with either MAGL or FAAH. Black and gray traces represent EPSCs before (baseline) and after (t = 38 min) stimulation, respectively. EPSCs were potentiated in the FAAH group but not in the MAGL group. B, Time course of percentage change of EPSC amplitude in the MAGL and FAAH groups. Each data point indicates the average of three consecutive EPSCs. Black bar above represents the presence of MAGL or FAAH in the pipette. C, Time course of PPF ratio from cells shown in B. D, Example EPSCs derived from a WT cell before (baseline) and after (t = 38 min) stimulation with bath application of AM251. Cells were stimulated for 5 min at 1 Hz. E, Time course of percentage change of EPSC amplitude. AM251 was locally applied before and during stimulation. Each data point indicates the average of three consecutive EPSCs. The mean EPSC amplitude at 38 min was 98 ± 6% of baseline (n = 12). p > 0.05 compared with baseline. F, Time course of PPF ratio from EPSCs shown in E.