Table 1.

Perceived inconsistencies in the amyloid cascade hypothesis emphasized by novel studies.

Findings	References
β-amyloid volume does not corelate well with the degree of memory loss.	Ingelsson et al., 2004; Huber et al., 2017; Kametani and Hasegawa, 2018
NFTs, neuronal loss and memory deficit have not been observed in BRI2-Aβ AD mouse model despite abundant β-amyloid deposits.	Kim et al., 2013
Neuroimaging studies visualized significant β-amyloid deposits in up to a third of elderly individuals with no memory loss.	Edison et al., 2007; Li et al., 2008; Rodrigue et al., 2013; Higashi et al., 2018
CNS infections were observed in some clinical trials after β-amyloid clearance.	Orgogozo et al., 2003; Alonso et al., 2018; Brothers et al., 2018