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. 2019 May 16;3(7):1423–1444. doi: 10.1210/js.2019-00004

Figure 4.

Figure 4.

OXT and OXTGly treatment improved glycemic control in lean and obese animals. (A) Effect of OXT (2 mg/kg, IP) on ipGTT in lean 16-wk-old C57BL/6 mice (n = 6 per group). (B) Effect of OXTGly (2 mg/kg, IP) on ipGTT in lean 16-wk-old C57BL/6 mice (n = 6 per group). (C) ipGTT study comparing OXT (2 mg/kg, IP) vs OXTGly (2 mg/kg, IP) in 16-wk-old DIO C57BL/6 mice (n = 6 per group). The curves were analyzed using two-way ANOVA followed by a Dunnett multiple comparisons test. An unpaired t test was used to analyze the AUC in panels (A) and (B); a one-way ANOVA followed by a Dunnett multiple comparisons test was used to analyze the AUC in panel (C). For all analyses: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.