Figure 5.
OXT stimulates insulin, glucagon, and GLP-1 secretion. OXT (2 mg/kg) (A–D) and OXTGly (2 mg/kg) (A′–D′) were IP injected into 16-wk-old C57BL/6 mice (n = 5 per group per time point) 30 min prior to the first blood hormone measurements. Mice were killed at given time points, and circulating hormones including insulin (A and A′), glucagon (B and B′), GLP-1 (C and C′), and active GIP (D and D′) were measured. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-way ANOVA followed by a Dunnett multiple comparisons test. An unpaired t test was used to analyze the AUC.