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. Author manuscript; available in PMC: 2020 Jun 6.
Published in final edited form as: Cell Stem Cell. 2019 May 23;24(6):974–982.e3. doi: 10.1016/j.stem.2019.05.003

Figure 4. Association of neurogenesis with cognitive diagnosis and presynaptic proteins.

Figure 4.

a,b. Logistic regression analysis of cognitive diagnosis and the number of DCX+PCNA+ cells shows significant correlation with MCI (p=0.038) (a) and borderline significance with MCI+AD (p=0.067) (b). c,d. Association between the number of DCX+PCNA+ (c) or Nestin+Sox2+Ki67+ (d) cells and global cognition score (p=0.046, p=0.098, respectively). e. Association between the number of DCX+PCNA+ cells and SNARE protein-protein interaction (p=0.0038). f. Representative image showing the distribution of presynaptic proteins in the dentate gyrus of the hippocampus inner molecular layer (IML), granule cell layer (GCL), subgranular layer (SGCL) and CA4 subfield. SNAP-25 immunostaining (magenta) with cell nuclei stained with DAPI (green) in a section of brain where DCX+PCNA+ cells were identified. Scale bar representes 25 μm.