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. 2019 Jun 26;10:1441. doi: 10.3389/fmicb.2019.01441

FIGURE 4.

FIGURE 4

Classification of late and early sputum culture converters in the IMPRESS cohort. (A) Pre-treatment time to MGIT culture positivity for IMPRESS participants with sputum culture conversion before 2 months (early converters) or with sputum culture conversion after 2 months (late converters). (B) ROC AUCs depicting 11-gene ACS COR signature discrimination between early and late sputum culture converters at baseline, month two or end of treatment. (C) 11-gene ACS COR signature scores for early and late sputum culture converters at baseline, month two or end of treatment. p-values were calculated using the Mann-Whitney U test. (D,E) Association between signature scores and time to liquid culture positivity at baseline (D) and 2 months after treatment start (E).