Table 4.

Performance of the COR signature as a triage test in HIV-infected and uninfected persons based on results from our diagnostic cohort.

HIV status	Sensitivity	Specificity	Number needed to screen∗	False positives	False negatives
WHO TTP for Triage test, optimal characteristics	>95%	>80%	<55	<11	1
ACS COR signature HIV-uninfected	100%	80%	50	10	0
ACS COR signature HIV-infected	65%	80%	77	16	1
Performance of current screening tools in HIV-infected persons
Symptom screening only∗∗	79%	50%	64	32	1
Symptom screening and chest radiography∗∗	91%	39%	55	33	1

TTP-Target product profile (World Health Organization [WHO], 2014). ^∗Number needed to screen to detect one case of TB. For these calculations a TB prevalence of 2% was used. False positives and negatives were calculated per number screened to detect one case of TB. ^∗∗Estimates for symptom screening and chest radiography are based on results from Getahun et al. (2011).