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. 2019 Aug;96(2):158–167. doi: 10.1124/mol.118.114827

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Fig. 4. — (A) Mithramycin reduced the expression of 10/11 hepatic transporters in primary human hepatocytes. (B) TCA, (C) GCA, (D) TCDCA, and (E) GCDCA accumulation was tested in primary human hepatocytes pretreated with DMSO, d4-CDCA, CsA, and mithramycin for 72 hours. (F) The amount of total bile acid after treatment was calculated as a percentage found in DMSO-treated cells. (G) The intracellular accumulation of all bile acids was combined and plotted as a percentage of DMSO-treated control cell values. ns, non-significant. *P < 0.05; and **P < 0.01.