Table 2.
Clinical and pathological characteristics of patients with pN+ UC and a FGFR3 mutation detected in cystectomy and/or positive lymph node.
| Patient | Age | Gender | Histology | Pathological stage | WHO1973 grade | AC | Relapse | Relapse type | Vital status | Follow-up (years) | Disease status | FGFR3 mutation | Mutated samples |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Int711 | 73 | M | UC | pT4aN2 | 3 | No | Yes | DM | Dead | 1.7 | DOD | S249C | T, N |
| Int1008 | 44 | F | UC + SCC | pT4aN2 | 3 | No | No | – | Alive | 0.7 | FOD | S249C | T |
| Int1015 | 39 | M | UC | pT4aN2 | 3 | No | Yes | DM | Alive | 1.1 | FOD | S249C | T |
| Int1028 | 78 | F | UC | pT4aN2 | 2 | Yes | No | – | Alive | 1.5 | FOD | S249C | T, N |
| Int3097 | 56 | F | UC | pT3bN2 | 3 | No | Yes | DM | Dead | 1.2 | DOD | R248C | T, N |
| Int3113 | 78 | M | UC + SCC | pT3aN2 | 3 | No | No | – | Alive | 9.4 | FOD | S249C | T, N |
| Int3125 | 75 | M | UC | pT3aN1 | 3 | No | Yes | DM | Dead | 1.1 | DOD | S249C | T |
| Int3180 | 62 | F | UC + SCC | pT4bN2 | 3 | No | Yes | DM | Dead | 0.4 | DOD | S249C | T, N |
| Int3280 | 81 | F | UC | pT3bN2 | 3 | No | Yes | DM | Dead | 1.9 | DOD | R248C | T, N |
| VCA023 | 77 | M | UC | pT3aN1 | 3 | Yes | No | – | Alive | 2 | FOD | S249C | T, N |
| VCA045 | 46 | M | UC | pT3bN2 | 3 | Yes | Yes | DM | Dead | 3.6 | DOD | S249C | T, N |
| VCA047 | 56 | M | UC | pT4aN1 | 3 | Yes | No | – | Alive | 11 | FOD | S249C | T, N |
| VCA090 | 59 | M | UC | pT4aN2 | 3 | Yes | Yes | DM | Dead | 2.6 | DOD | S249C | T, N |
In three cases, the node sample was not available.
AC, adjuvant chemotherapy; M, male; F, female; UC, urothelial carcinoma; UC + SCC, urothelial carcinoma with squamous differentiation; T, tumor; N, node; DM, distant metastasis; FOD, free of disease; DOD, dead of disease.