Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 8;6(Pt 4):572–585. doi: 10.1107/S2052252519005372

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Tatiana Barros Cereija et al. 2019

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

PMC Copyright notice

Closed and open conformations of MhGgH. Solid-surface representation coloured according to electrostatic potential [contoured from −8 kT/e (red) to 8 kT/e (blue)] (upper panel) and cross-section (lower panel) of MhGgH in closed (left) and open (right) conformations. In the closed state (left), the active-site cavity (marked with an asterisk) becomes inaccessible to the solvent. In the open state (right), an opening leading to an acidic cavity is observed (dashed ellipse; upper panel); a negatively charged tunnel (arrow) connects the active-site cavity to the exterior of the molecule (lower panel). Substrate-binding residues are highlighted in yellow. The left and right poses in each panel are related by 25° and 45° rotation around x and y, respectively.