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. 2019 Jul 3;14(7):e0218397. doi: 10.1371/journal.pone.0218397

Table 2. Names and sources of Culex quinquefasciatus genes included in the targeted sequencing panel.

SC Gene ID Name from Vectorbase Sourcea Comments
1 CPIJ000049 carboxylesterase A Culex expansion geneb
1 CPIJ000050 carboxylesterase A Culex expansion gene
1 CPIJ000051 carboxylesterase A Culex expansion gene
2 CPIJ000304 GST D2 A Culex expansion gene
9 CPIJ000926 cytochrome P450 C upregulated
12 CPIJ001038 cytochrome P450 CYP18A1 E
12 CPIJ001081 beta, beta-carotene 15,15'-monooxygenase E
15 CPIJ001240 cathepsin B-like thiol protease B upregulated
25 CPIJ001746 conserved hypothetical protein D downregulated
25 CPIJ001759 cytochrome P450 CYP4H40 C upregulated
23 CPIJ001836 cuticle protein D downregulated
21 CPIJ002128 mast cell protease 2 precursor B upregulated
21 CPIJ002130 kallikrein-7 precursor B upregulated
21 CPIJ002135 trypsin alpha-4 precursor B upregulated
35 CPIJ002538 cytochrome P450 CYP6AG12 C, B upregulated
42 CPIJ002629 sensory appendage protein, putative D downregulated
36 CPIJ002663 Glutathione S-transferase 1–1 A
36 CPIJ002678 Glutathione transferase I A Culex expansion gene
36 CPIJ002679 Glutathione S-transferase theta-2 A Culex expansion gene
36 CPIJ002680 Glutathione S-transferase A Culex expansion gene
36 CPIJ002681 Glutathione S-transferase A Culex expansion gene
46 CPIJ002809 conserved hypothetical protein D downregulated
39 CPIJ003082 cytochrome P450 CYP9J42 C upregulated
50 CPIJ003558 deoxyhypusine hydroxylase E
53 CPIJ003623 coagulation factor XII precursor B upregulated
60 CPIJ004086 angiotensin-converting enzyme B upregulated
73 CPIJ004532 40S ribosomal protein S17 F Aedes housekeeping gene ortholog
86 CPIJ005332  cytochrome P450 CYP9J43 C upregulated
104 CPIJ005953 cytochrome P450 CYP6BB3 B, C upregulated
104 CPIJ005954 cytochrome P450 CYP6CC2 B, C upregulated
104 CPIJ005955 cytochrome P450 CYP6P14 B, C upregulated
104 CPIJ005956 cytochrome P450 CYP6BZ2 B, C upregulated
104 CPIJ005957 cytochrome P450 CYP6AA9 B, C upregulated
104 CPIJ005959  cytochrome P450 CYP6AA7 B, C upregulated
106 CPIJ006034c acetylcholinesterase G
106 CPIJ006067 ATP synthase B chain, mitochondrial D upregulated
106 CPIJ006068 utp-glucose-1-phosphate uridylyltransferase 2 D upregulated
109 CPIJ006160 Glutathione s-transferase B upregulated
121 CPIJ006542 chymotrypsin-2 B upregulated
156 CPIJ006721 cytochrome P450 CYP4H37 B upregulated
139 CPIJ007047 serine/arginine rich splicing factor D downregulated
140 CPIJ007135 juvenile hormone esterase A Culex expansion gene
163 CPIJ007188 cytochrome P450 CYP4H30 B upregulated
182 CPIJ007593 sodium channel protein para G
182 CPIJ007594 Voltage-dependent para-like sodium channel G
182 CPIJ007595 Sodium channel protein G
182 CPIJ007596 Voltage-gated sodium channel G
171 CPIJ007825 para-nitrobenzyl esterase A Culex expansion gene
196 CPIJ008566 cytochrome P450 CYP6Z15 C upregulated
228 CPIJ009085 cytochrome P450 CYP6AG13 B upregulated
241 CPIJ009106 angiotensin-converting enzyme precursor B upregulated
224 CPIJ009364d anamorsin, putative D downregulated
229 CPIJ009404 trehalose-6-phosphate synthase D upregulated
234 CPIJ009415 cytochrome P450 CYP4G36 E
247 CPIJ009474 cytochrome P450 CYP4D40 H
247 CPIJ009478 cytochrome P450 CYP4D42 B, C upregulated
240 CPIJ009578  CRAL/TRIO domain-containing protein D upregulated
252 CPIJ009715  putative uncharacterized protein D upregulated
279 CPIJ010227 cytochrome P450 CYP12F13 B, H, C upregulated
261 CPIJ010238d GLP_748_1200_211 (Fragment) E
277 CPIJ010480 cytochrome P450 CYP4J20 E
278 CPIJ010537 cytochrome P450 CYP9J45 B, C upregulated
278 CPIJ010538 cytochrome P450 CYP9J46 B, A upregulated
278 CPIJ010543 cytochrome P450 CYP9J40 B, H upregulated
278 CPIJ010544 cytochrome P450 CYP9J33 B, H, C upregulated
278 CPIJ010546 cytochrome P450 CYP9J34 B, H, C upregulated
278 CPIJ010548 cytochrome P450 CYP9J39 H, C upregulated
281 CPIJ010805 carboxypeptidase A1 precursor B upregulated
293 CPIJ010814 Glutathione S-transferase 1–5 A Culex expansion gene
332 CPIJ010858 cytochrome P450 CYP6F1 H
313 CPIJ011127 cytochrome P450 CYP4H34 B, A upregulated
328 CPIJ011693 NADH-ubiquinone oxidoreductase 42 kda subunit D upregulated
392 CPIJ012406d histone cluster 1, putative D upregulated
392 CPIJ012466 pupal cuticle protein 78E, putative D downregulated
392 CPIJ012470 cytochrome P450 CYP9AL1 B, C upregulated
435 CPIJ012935 thymosin isoform 1 D downregulated
426 CPIJ013027 gut esterase 1 precursor A Culex expansion gene
448 CPIJ013319 metalloproteinase, putative  B upregulated
469 CPIJ013503 NADH dehydrogenase iron-sulfur protein 3 D upregulated
464 CPIJ013721 dimethylaniline monooxygenase E
464 CPIJ013723 dimethylaniline monooxygenase E
464 CPIJ013725 dimethylaniline monooxygenase E
512 CPIJ013917 esterase B1 precursor G esterase
512 CPIJ013918 esterase B1 precursor G esterase
510 CPIJ014218 cytochrome P450 CYP9M10 B, C upregulated
561 CPIJ014523 elastase-3A precursor B upregulated
631 CPIJ015248 zinc-finger protein H
728 CPIJ015681 cytochrome P450 CYP4H37 H, B upregulated
730 CPIJ015958 cytochrome P450 CYP325BC1 B, A upregulated
832 CPIJ016012 tryptase-2 B upregulated
729 CPIJ016026  carboxylesterase A Culex expansion gene
753 CPIJ016284 cytochrome P450 CYP4J4 E
792 CPIJ016681 esterase FE4 precursor A Culex expansion gene
963 CPIJ017123 Myosin light chain 2 I
970 CPIJ017198 cytochrome P450 CYP325BF1-de1b E
938 CPIJ017243 cytochrome P450 CYP304B4 B upregulated
984 CPIJ017326 odorant binding protein OBP43 D downregulated
977 CPIJ017331 cuticle protein CP14.6 precursor D upregulated
944 CPIJ017479 conserved protein, putative D upregulated
1030 CPIJ017763 juvenile hormone esterase precursor A Culex expansion gene
1170 CPIJ017894 voltage-gated sodium channel J
1170 CPIJ017895 voltage-dependent para-like sodium channel J
1170 CPIJ017896 voltage-gated sodium channel J
1118 CPIJ018232 cholinesterase A Culex expansion gene
1118 CPIJ018233 carboxylesterase A Culex expansion gene
1199 CPIJ018377 T-complex protein 1 subunit epsilon D upregulated
1224 CPIJ018624 Glutathione-s-transferase theta, gst A Culex expansion gene
1224 CPIJ018626 Glutathione-s-transferase theta, gst A Culex expansion gene
1224 CPIJ018627 Glutathione S-transferase 1–1 A Culex expansion gene
1224 CPIJ018628 Glutathione S-transferase E2 A Culex expansion gene
1224 CPIJ018629 Glutathione-s-transferase theta, gst A Culex expansion gene
1224 CPIJ018630 Glutathione S-transferase 1–1 A Culex expansion gene
1224 CPIJ018631 Glutathione-s-transferase theta, gst A Culex expansion gene
1224 CPIJ018632d Glutathione-s-transferase theta, gst A upregulated
1387 CPIJ018943 cytochrome P450 CYP4C52 C upregulated
1643 CPIJ019395 cytochrome P450 CYP4C52 E
2838 CPIJ019428 trypsin 2 precursor B upregulated
2060 CPIJ019703 cytochrome P450 CYP6Y6 E
2176 CPIJ020030 fork head domain transcription factor slp2 I
3121 CPIJ020082 cytochrome P450 CYP6F6 E
2594 CPIJ020229 cytochrome P450 CYP4D42 B, C upregulated

aA = [56], B = [48], C = [49], D = [50], E = Vectorbase search for monooxygenase genes, F = [62], G = Known insecticide resistance gene, H = Biomart search for Culex detoxification genes, I = [63], J = likely repeats of voltage-gated sodium channel gene.

bCulex expansion gene = as proposed by [55]

cPrimers designed but no PCR products made for this gene.

dPrimer design process was unable to find suitable primers for this gene so it was excluded.