Fig 7. Resurgent Na+ current offers burst stability and noise modulation.
a—c) Simulated membrane voltage shows neural activity patterns without any gNaR (a), with additive Gaussian noise input (b), and with subsequent addition of gNaR (c). Expanded regions in (a-c) show membrane voltage sub-threshold oscillations (STO) during an inter-burst interval. Also overlaid is the evolution of the slow sodium inactivation/recovery variable; arrow indicates recovery during IBI, and magenta circle marks an arbitrary time point used to track these trajectories in (d—f). d—f) Bifurcation diagrams with projected trajectories of (h∞,V), shown in magenta to highlight the effect of addition of noise near sub-threshold voltages (e) and then the enlarged region of noise tolerance (highlighted green shaded region) due to addition of gNaR in (f). The magenta circle marks the beginning time points of each trajectory.