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. 2019 Mar 8;27(4):363–372. doi: 10.4062/biomolther.2018.211

Fig. 2.

Fig. 2.

Effects of 7,8,4′-THIF on viability (A) of SH-SY5Y cells. Dose-dependent cytotoxic effects of 6-OHDA on viability (B) of SH-SY5Y cells. Protective effects of 7,8,4′-THIF on 6-OHDA-induced neuronal cell death (C) and LDH release (D) in SH-SY5Y cells. The cells were pretreated with 7,8,4′-THIF (2.5, 5, 10, 25, or 50 μM) for 30 min followed by exposure to 200 μM 6-OHDA for 24 h. The viability of the cells and LDH release were assessed using MTT and LDH assays, respectively, and are expressed as a percentage of the corresponding values for the control group.The data are presented as mean ± SEM (n=6). *p<0.05 and ***p<0.001 compared with the control group. ###p<0.001 compared with the 6-OHDA-treated group.