Skip to main content
. Author manuscript; available in PMC: 2019 Jul 3.
Published in final edited form as: Oncogene. 2016 Nov 14;36(12):1607–1618. doi: 10.1038/onc.2016.312

Figure 4. PTEN A126G has altered enzymatic activity.

Figure 4.

WT PTEN inhibits the activation of PI53K/AKT signaling by dephosphorylating PI(3,4,5)P3 and PI(3,4)P2 to PI(4,5)P2 and PI(4)P respectively. PTEN A126G, when compared to WT PTEN, dephosphorylates PI(3,4,5)P3 at reduced rate. Moreover, PTEN A126G displays a shift in enzymatic specificity toward 5’ phosphoinositides, resulting in the production of PI(3,4)P2 rather than PI(4,5)P2 which is produced by WT PTEN. The accumulation of PI(3,4,5)P2 and PI(3,4)P2 together leads to AKT and S6 phosphorylation and ultimately cell motility.