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. 2019 May 28;101(1):180–188. doi: 10.4269/ajtmh.18-0882

Table 4.

Factors related to mortality in patients with yellow fever, Institute of Infectology Emilio Ribas, 2018

Laboratory results	OR_unadjusted (CI 95%)	P-value	Model 1*		Model 2†
Laboratory results	OR_unadjusted (CI 95%)	P-value	OR_adjusted (CI 95%)	P-value	OR_adjusted (CI 95%)	P-value
Age (one year)	1.078 (1.034–1.123)	0.001	1.105 (1.008–1.212)	0.033	1,136 (1,013–1,275)	0.030
Leukocytes (cells/mm³) (100 U/L)	1.044 (1.018–1.071)	0.001
Platelets (cells/mm³) (1,000 U/L)	0.996 (0.997–0.999)	0.030
Total bilirubin (mg/dL)	1.455 (1.193–1.773)	< 0.001
Direct bilirubin (mg/dL)	1.521 (1.216–1.902)	< 0.001
Aspartate aminotransferase (U/L) (100 U/L)	1.043 (1.021–1.066)	< 0.001	1.038 (1.005–1.072)	0.023
Alanine aminotransferase (U/L) (100 U/L)	1.086 (1.039–1.136)	< 0.001			1.118 (1.018–1.228)	0.020
International normalized ratio (seconds)	1.873 (1.108–3.165)	0.019
Urea (mg/dL)	1.040 (1.021–1.058)	< 0.001
Creatinine (mg/dL)	2.833 (1.570–5.111)	0.001	2.343 (1.205–4.553)	0.012	2.835 (1.352–5.941)	0.006
Creatine phosphokinase (U/L)	1.001 (1.00–1.001)	0.113
Time between onset of symptoms and hospital admission (days)	0.903 (0.767–1.062)	0.216	0.885 (0.546–1.276)	0.404	0.779 (0.449–1,218)	0.273

OR = odds ratio.

* Hosmer and Lemeshow test = 0.907.

† Hosmer and Lemeshow test = 0.998.