Table 2.

Performance of the different assays for the diagnosis of cutaneous leishmaniasis by classical validation (2 × 2) (95% CI) (qPCR as gold standard)

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	LR+	LR−	Kappa (κ)
Microscopy	82 (70–90)	90.9 (70–98)	95.3 (89–100)	69 (52.1–85.8)	9 (2.3–43)	0.19 (0.1–0.3)	0.66
LAMP	84 (71.1–91.8)	100 (82–100)	100 (100–100)	73.3 (57.5–89.2)	–	0.16 (0.08–0.30)	0.76
PCR	54 (40.4–67)	100 (82.1–100)	100 (100–100)	48.9 (34.3–63.5)	–	0.46 (0.3–0.6)	0.41

LAMP = loop-mediated isothermal amplification; LR = likelihood ratio; NPV = negative predictive value; PPV = positive predictive value.