Table 1. Baseline characteristics of 12 included trials.

authors	phase	total	treatment arms	median age (years)	median PFS	No. for analysis
Lam E.T. et al. 2010 [40]	II	16	sorafenib 400 mg bid po	60	17.9	16
Wells Jr S.A. et al. 2012 [39]	III	331	vandetanib 300 mg qd po	50.7	30.5	231
			placebo	53.4	19.3	100
Savvides P. et al. 2013 [37]	II		sorafenib 400 mg bid po	59	1.9	20
Elisei R. et al. 2013 [38]	III	330	cabozantinib 140 mg qd po	55	11.4	214
			placebo	55	4	109
Brose M.S. et al. 2014 [36]	III	416	sorafenib 400 mg bid po	63	10.8	207
			placebo	63	5.8	209
Cohen E.E.W. et al. 2014 [35]	II	60	axitnib 5 mg bid po	59	15	60
Cabanillas M.E. et al. 2015 [30]	II	58	lenvatinib 24 mg qd po	63	12.6	58
Schlumberger M. et al. 2015 [31]	III	392	lenvatinib 24 mg qd po	64	18.3	261
			placebo	61	3.6	131
Bikas A. et al. 2016 [32]	II	23	sunitnib 50 mg qd	61	8	23
Schlumberger M. et al. 2016 [33]	II	59	lenvatinib 24 mg qd po	51.6	9	59
Cabonillas M.E. et al. 2017 [34]	II	25	cabozantinib 140 mg qd po	64	12.7	25
Ravaud A. et al. 2017 [29]	II	71	sunitinib 50 mg qd	66	13.1	71

Abbreviation: PFS, progression-free survival.