Figure 1. Representative exonic somatic mutations in 16 early-stage esophageal squamous cell carcinoma (ESCC) samples (High-grade intraepithelial neoplasm 6, T1a 7, T1b 3 samples).

(Upper panel) The number of somatic mutations per sample. Yellow bars indicate the number of single nucleotide variants and blue bars indicate the number of indels. (Lower panel) Percentage of recurrently mutated genes (genes mutated in more than 3 patients with a mutation rate of > 10 mutation/Mb. Main panels show mutation type of these 11 genes, history of alcohol and smoking, risk SNPs, and tumor depth. Right, bar-graph shows non-silent mutations for each gene.