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. 2019 Jun 27;13:291. doi: 10.3389/fncel.2019.00291

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Copyright © 2019 Quinn, Kolar, Harris, Wigerius, Fawcett and Krueger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DREADD-mediated silencing does not affect synapse turnover. (A) Micrographs of stable (filled arrowheads), eliminated (open arrowheads) and formed (asterisks) synapses in control and DREADD-treated cultures. (B) The fraction of newly formed synapses in DREADD-treated cultures (36.5 ± 3.4%) and control cultures (29.6 ± 2.5%) was not significantly different (n = 24 neurons over three cultures; p = 0.111, t(46) = 1.62, Student’s t-test). (C) The fraction of eliminated synapses in DREADD-treated cultures (31.5 ± 3.6%) and control cultures (32.2 ± 2.7%) was similar (n = 24; p = 0.865, t(46) = 0.17, Student’s t-test). Data are shown as mean ± SEM. Scale bar = 1 μm.