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. 2019 May 28;42(2):533–548. doi: 10.3892/or.2019.7173

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — (A) Protein-protein interaction (PPI) network of the target genes of the top 3 most highly upregulated differentially expressed miRNAs (DEMs). (B) PPI network of the target genes of the top 3 most highly downregulated DEMs. Node size indicates the connectivity degree, and larger circles indicate a higher degree. Edge size indicates the combined scores between genes, which represent the confidence of protein interactions. The color gradually increases from dark (blue) to bright (red), representing the gradually increase in the number of interacting genes.