Table I.

Top 10 upregulated and downregulated DEMs between aggressive and nonaggressive prolactin pituitary tumors.

miRNAs (DEMs)	P-value	t	B	logFC
Upregulated
hsa-miR-489	0.00677	3.25	−4.58	7.07
hsa-let-7d*	0.02591	2.53	−4.58	6.09
hsa-miR-138-1*	0.02569	2.54	−4.58	5.26
hsa-miR-886-3p	0.00191	3.94	−4.58	4.36
hsa-miR-576-5p	0.04773	2.2	−4.59	3.83
hsa-miR-135b	0.01671	2.77	−4.58	3.72
hsa-miR-137	0.03877	2.32	−4.59	3.29
hsa-miR-886-3p	0.00235	3.82	−4.58	3.2
hsa-miR-551b	0.02074	2.66	−4.58	3.04
hsa-miR-296-3p	0.04524	2.23	−4.59	3.02
Downregulated
hsa-miR-520b	0.00732	−3.21	−4.58	−6.36
hsa-miR-875-5p	0.04037	−2.29	−4.59	−5.66
hsa-miR-671-3p	0.01453	−2.85	−4.58	−5.49
hsa-miR-372	0.00348	−3.61	−4.58	−5.49
hsa-miR-586	0.02631	−2.53	−4.58	−5.44
hsa-miR-367*	0.02421	−2.57	−4.58	−4.84
hsa-miR-302b	0.01052	−3.02	−4.58	−4.49
hsa-miR-187	0.0322	−2.42	−4.59	−4.35
hsa-miR-193b*	0.02207	−2.62	−4.58	−4.31
hsa-miR-452*	0.00322	−3.65	−4.58	−4.17

miRNA names with ‘*’ are also mature miRNAs as annotated in miRBase (http://www.mirbase.org). For example, hsa-let-7d* is hsa-let-7d-3p; hsa-miR-138-1* is hsa-miR-138-1-3p; hsa-miR-367* is hsa-miR-367-5p; hsa-miR-193b* is hsa-miR-193b-5p; hsa-miR-452* is hsa-miR-452-3p. DEMs, differentially expressed miRNAs; hsa, Homo sapiens.