Table II.
Functional and pathway enrichment analysis for target genes of the top 3 upregulated miRNAs.
| Category | Term | Pathway description | Count | P-value |
|---|---|---|---|---|
| Upregulated miRNAs | ||||
| GO BP | GO:0060412 | Ventricular septum morphogenesis | 3 | 0.020464503 |
| GO BP | GO:0007286 | Spermatid development | 4 | 0.021020749 |
| GO BP | GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | 12 | 0.021742388 |
| GO BP | GO:0006351 | Transcription, DNA-templated | 24 | 0.022393279 |
| GO BP | GO:0030154 | Cell differentiation | 9 | 0.025194909 |
| GO BP | GO:0097411 | Hypoxia-inducible factor-1α signaling pathway | 2 | 0.030146509 |
| GO BP | GO:0030177 | Positive regulation of Wnt signaling pathway | 3 | 0.030678983 |
| GO BP | GO:0007165 | Signal transduction | 16 | 0.030948235 |
| GO BP | GO:0030336 | Negative regulation of cell migration | 4 | 0.036066871 |
| GO BP | GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 14 | 0.03646379 |
| GO CC | GO:0005737 | Cytoplasm | 52 | 0.0134897 |
| GO CC | GO:0031519 | PcG protein complex | 3 | 0.016939042 |
| GO CC | GO:0005634 | Nucleus | 52 | 0.026624876 |
| GO CC | GO:0005794 | Golgi apparatus | 13 | 0.026655792 |
| GO CC | GO:0005654 | Nucleoplasm | 29 | 0.053523267 |
| GO CC | GO:0031526 | Brush border membrane | 3 | 0.054869988 |
| GO CC | GO:0000139 | Golgi membrane | 9 | 0.072820488 |
| GO CC | GO:0044798 | Nuclear transcription factor complex | 2 | 0.078554642 |
| GO CC | GO:0005829 | Cytosol | 32 | 0.094144731 |
| GO MF | GO:0005515 | Protein binding | 83 | 0.007060503 |
| GO MF | GO:0050693 | LBD domain binding | 2 | 0.030452531 |
| GO MF | GO:0003700 | Transcription factor activity, sequence-specific DNA binding | 14 | 0.034027538 |
| GO MF | GO:0001077 | Transcriptional activator activity, RNA polymerase II core sequence-specific binding | 6 | 0.035934263 |
| GO MF | GO:0030620 | U2 snRNA binding | 2 | 0.045331887 |
| GO MF | GO:0008517 | Folic acid transporter activity | 2 | 0.052686367 |
| GO MF | GO:0001078 | Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 4 | 0.054345955 |
| GO MF | GO:0004726 | Non-membrane spanning protein tyrosine phosphatase activity | 2 | 0.059984623 |
| GO MF | GO:0003714 | Transcription corepressor activity | 5 | 0.071931973 |
| GO MF | GO:0004871 | Signal transducer activity | 5 | 0.07295342 |
| KEGG | hsa04310 | Wnt signaling pathway | 5 | 0.006641183 |
| KEGG | hsa04022 | cGMP-PKG signaling pathway | 5 | 0.01255563 |
| KEGG | hsa05211 | Renal cell carcinoma | 3 | 0.049309583 |
In the event there were more than five terms enriched in this category, the top 5 terms were selected per P-value. GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; Count, numbers of enriched genes in each term; hsa, Homo sapiens.