Table III.
Functional and pathway enrichment analysis for target genes of the top 3 downregulated miRNAs.
| Category | Term | Description | Count | P-value |
|---|---|---|---|---|
| Downregulated miRNAs | ||||
| GO BP | GO:0046777 | Protein autophosphorylation | 15 | 0.000170888 |
| GO BP | GO:0006355 | Regulation of transcription, DNA-templated | 59 | 0.001639464 |
| GO BP | GO:0006357 | Regulation of transcription from RNA polymerase II promoter | 23 | 0.002882721 |
| GO BP | GO:0016567 | Protein ubiquitination | 20 | 0.002898481 |
| GO BP | GO:0006351 | Transcription, DNA-templated | 71 | 0.003602574 |
| GO BP | GO:0006123 | Mitochondrial electron transport, cytochrome c to oxygen | 4 | 0.014446477 |
| GO BP | GO:0042119 | Neutrophil activation | 3 | 0.017126856 |
| GO BP | GO:0007223 | Wnt signaling pathway, calcium modulating pathway | 5 | 0.018278676 |
| GO BP | GO:0008654 | Phospholipid biosynthetic process | 5 | 0.019902891 |
| GO BP | GO:0048468 | Cell development | 5 | 0.019902891 |
| GO CC | GO:0005654 | Nucleoplasm | 112 | 6.68468E-07 |
| GO CC | GO:0005634 | Nucleus | 170 | 0.001202665 |
| GO CC | GO:0017053 | Transcriptional repressor complex | 7 | 0.002719148 |
| GO CC | GO:0005758 | Mitochondrial intermembrane space | 8 | 0.002811554 |
| GO CC | GO:0005813 | Centrosome | 22 | 0.003323275 |
| GO CC | GO:0005739 | Mitochondrion | 50 | 0.006368195 |
| GO CC | GO:0031463 | Cul3-RING ubiquitin ligase complex | 7 | 0.007248149 |
| GO CC | GO:0005829 | Cytosol | 106 | 0.009417134 |
| GO CC | GO:0015629 | Actin cytoskeleton | 13 | 0.010602362 |
| GO CC | GO:0005741 | Mitochondrial outer membrane | 10 | 0.014535489 |
| GO MF | GO:0005515 | Protein binding | 269 | 9.14069E-05 |
| GO MF | GO:0003677 | DNA binding | 62 | 0.004456722 |
| GO MF | GO:0004842 | Ubiquitin-protein transferase activity | 18 | 0.005935513 |
| GO MF | GO:0003700 | Transcription factor activity, sequence-specific DNA binding | 39 | 0.006954496 |
| GO MF | GO:0004672 | Protein kinase activity | 18 | 0.013435998 |
| GO MF | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | 5 | 0.013877869 |
| GO MF | GO:0003707 | Steroid hormone receptor activity | 6 | 0.015112205 |
| GO MF | GO:0043565 | Sequence-specific DNA binding | 23 | 0.017535243 |
| GO MF | GO:0031625 | Ubiquitin protein ligase binding | 15 | 0.018757483 |
| GO MF | GO:0004674 | Protein serine/threonine kinase activity | 18 | 0.020173241 |
| KEGG | hsa05162 | Measles | 10 | 0.005987506 |
| KEGG | hsa05215 | Prostate cancer | 8 | 0.006312095 |
| KEGG | hsa05200 | Pathways in cancer | 19 | 0.009215433 |
| KEGG | hsa05205 | Proteoglycans in cancer | 12 | 0.011467731 |
| KEGG | hsa05219 | Bladder cancer | 5 | 0.018691786 |
| KEGG | hsa04962 | Vasopressin-regulated water reabsorption | 5 | 0.023655555 |
| KEGG | hsa04919 | Thyroid hormone signaling pathway | 8 | 0.023895596 |
| KEGG | hsa05164 | Iinfluenza A | 10 | 0.030429321 |
| KEGG | hsa05218 | Melanoma | 6 | 0.032052212 |
| KEGG | hsa04390 | Hippo signaling pathway | 9 | 0.035379929 |
If there were more than five terms enriched in this category, the top 5 terms were selected per the P-value. GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; Count, numbers of enriched genes in each term; hsa, Homo sapiens.