Table V.
Functional and pathway enrichment analysis for the hub genes of the top 3 upregulated miRNAs.
| Category | Term | Pathway description | Genes |
|---|---|---|---|
| Upregulated miRNAs | |||
| GO BP | GO:0032364 | Oxygen homeostasis | HIF1A |
| GO BP | GO:0032909 | Regulation of transforming growth factor β2 production | HIF1A |
| GO BP | GO:0033483 | Gas homeostasis | HIF1A |
| GO BP | GO:0032642 | Regulation of chemokine production | SNAI2, HIF1A |
| GO BP | GO:0046885 | Regulation of hormone biosynthetic process | HIF1A |
| GO BP | GO:0043619 | Regulation of transcription from RNA polymerase II promoter in response to oxidative stress | HIF1A |
| GO BP | GO:0070099 | Regulation of chemokine-mediated signaling pathway | HIF1A |
| GO BP | GO:0032352 | Positive regulation of hormone metabolic process | HIF1A |
| GO BP | GO:0010839 | Negative regulation of keratinocyte proliferation | SNAI2 |
| GO BP | GO:0071364 | Cellular response to epidermal growth factor stimulus | SNAI2, PTPN11 |
| GO CC | GO:0031528 | Microvillus membrane | PDPN |
| GO CC | GO:0000243 | Commitment complex | SNRPD3 |
| GO CC | GO:0005683 | U7 snRNP | SNRPD3 |
| GO CC | GO:0005687 | U4 snRNP | SNRPD3 |
| GO CC | GO:0034709 | Methylosome | SNRPD3 |
| GO CC | GO:0031527 | Filopodium membrane | PDPN |
| GO CC | GO:0071437 | Invadopodium | PDPN |
| GO CC | GO:0031011 | Ino80 complex | YY1 |
| GO CC | GO:0005685 | U1 snRNP | SNRPD3 |
| GO CC | GO:0031258 | Lamellipodium membrane | PDPN |
| GO MF | GO:0000400 | Four-way junction DNA binding | YY1 |
| GO MF | GO:0001227 | Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | YY1, SNAI2 |
| GO MF | GO:0019956 | Chemokine binding | PDPN |
| GO MF | GO:0043565 | Sequence-specific DNA binding | YY1, SNAI2, HIF1A |
| GO MF | GO:0061631 | Ubiquitin conjugating enzyme activity | UBE2D1 |
| GO MF | GO:0000217 | DNA secondary structure binding | YY1 |
| GO MF | GO:0061650 | Ubiquitin-like protein conjugating enzyme activity | UBE2D1 |
| GO MF | GO:0005158 | Insulin receptor binding | PTPN11 |
| GO MF | GO:0035326 | Enhancer binding | YY1 |
| GO MF | GO:0001078 | Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | YY1, SNAI2 |
| KEGG | hsa05211 | Renal cell carcinoma | PTPN11, HIF1A |
| KEGG | hsa05205 | Proteoglycans in cancer | PTPN11, HIF1A |
| KEGG | hsa04150 | mTOR signaling pathway | HIF1A |
| KEGG | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | PTPN11 |
| KEGG | hsa05230 | Central carbon metabolism in cancer | HIF1A |
| KEGG | hsa05220 | Chronic myeloid leukemia | PTPN11 |
| KEGG | hsa04920 | Adipocytokine signaling pathway | PTPN11 |
| KEGG | hsa04520 | Adherens junction | SNAI2 |
| KEGG | hsa05231 | Choline metabolism in cancer | HIF1A |
| KEGG | hsa04066 | HIF-1 signaling pathway | HIF1A |
GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; hsa, Homo sapiens.