Table VI.
Functional and pathway enrichment analysis for the hub genes of top 3 downregulated miRNAs.
| Category | Term | Pathway description | Genes |
|---|---|---|---|
| Downregulated miRNAs | |||
| GO BP | GO:0070141 | Response to UV-A | CCND1, EGFR |
| GO BP | GO:0097193 | Intrinsic apoptotic signaling pathway | CDKN1A, CUL3, DNAJC10, CYCS |
| GO BP | GO:0032355 | Response to estradiol | CTNNB1, ESR1, EGFR |
| GO BP | GO:1903798 | Regulation of production of miRNAs involved in gene silencing by miRNA | ESR1, EGFR |
| GO BP | GO:0033674 | Positive regulation of kinase activity | CDKN1A, EGFR, IGF1R |
| GO BP | GO:0001934 | Positive regulation of protein phosphorylation | CDKN1A, CCND1, EGFR, IGF1R |
| GO BP | GO:0045737 | Positive regulation of cyclin-dependent protein serine/threonine kinase activity | CCND1, EGFR |
| GO BP | GO:0045740 | Positive regulation of DNA replication | EGFR, IGF1R |
| GO BP | GO:0006367 | Transcription initiation from RNA polymerase II promoter | CDKN1A, CCND1, ESR1 |
| GO BP | GO:0034333 | Adherens junction assembly | CTNNB1 |
| GO CC | GO:0030128 | Clathrin coat of endocytic vesicle | EGFR |
| GO CC | GO:0030122 | AP-2 adaptor complex | EGFR |
| GO CC | GO:0030131 | Clathrin adaptor complex | EGFR |
| GO CC | GO:1990907 | β-catenin-TCF complex | CTNNB1 |
| GO CC | GO:0005719 | Nuclear euchromatin | CTNNB1 |
| GO CC | GO:0000791 | Euchromatin | CTNNB1 |
| GO CC | GO:0035327 | Transcriptionally active chromatin | ESR1 |
| GO CC | GO:0000790 | Nuclear chromatin | CTNNB1, ESR1 |
| GO CC | GO:0005758 | Mitochondrial intermembrane space | CYCS |
| GO CC | GO:0016342 | Catenin complex | CTNNB1 |
| GO MF | GO:0097472 | Cyclin-dependent protein kinase activity | CDKN1A, CCND1 |
| GO MF | GO:0019900 | Kinase binding | CDKN1A, CCND1, CTNNB1, ESR1 |
| GO MF | GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | CDKN1A, CCND1 |
| GO MF | GO:0004709 | MAP kinase kinase kinase activity | EGFR, IGF1R |
| GO MF | GO:0001223 | Transcription coactivator binding | ESR1 |
| GO MF | GO:0044389 | Ubiquitin-like protein ligase binding | CDKN1A, CUL3, EGFR |
| GO MF | GO:0019901 | Protein kinase binding | CDKN1A, CCND1, ESR1, EGFR, IGF1R |
| GO MF | GO:0030331 | Estrogen receptor binding | CTNNB1, ESR1 |
| GO MF | GO:0016671 | Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | DNAJC10 |
| GO MF | GO:0046934 | Phosphatidylinositol-4,5-bisphosphate 3-kinase activity | ESR1, EGFR |
| KEGG | hsa05205 | Proteoglycans in cancer | CDKN1A, CCND1, ESR1, CTNNB1, EGFR, IGF1R |
| KEGG | hsa05215 | Prostate cancer | CDKN1A, CCND1, CTNNB1, EGFR, IGF1R |
| KEGG | hsa05200 | Pathways in cancer | CDKN1A, CCND1, CTNNB1, CYCS, EGFR, IGF1R |
| KEGG | hsa05214 | Glioma | CDKN1A, CCND1, EGFR, IGF1R |
| KEGG | hsa05218 | Melanoma | CDKN1A, CCND1, EGFR, IGF1R |
| KEGG | hsa04068 | FoxO signaling pathway | CDKN1A, CCND1, EGFR, IGF1R |
| KEGG | hsa04510 | Focal adhesion | CCND1, CTNNB1, EGFR, IGF1R |
| KEGG | hsa05213 | Endometrial cancer | CCND1, CTNNB1, EGFR |
| KEGG | hsa05219 | Bladder cancer | CDKN1A, CCND1, EGFR |
| KEGG | hsa05210 | Colorectal cancer | CCND1, CYCS, CTNNB1 |
GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes; hsa, Homo sapiens.