Table 2. HRs for the risk of MDD associated with PD.

Variables		HR	95% CI	P value	HR	95% CI	P value
Overall
	Without PD	1	-	-	-	-	-
	With PD	9.638	7.203–12.896	< 0.001	1.518	1.147–2.009	0.004
Stratification by time
	Without PD	1	-	-	1	-	-
	With PD, 0	19.244	14.47–25.591	< 0.001	1.626	1.034–2.556	0.035
	With PD, 1–2 yr	12.680	6.240–25.763	< 0.001	2.248	1.167–4.328	0.015
	With PD, 3–5 yr	4.439	1.782–11.055	< 0.001	1.008	0.587–1.731	0.977
	With PD, 6–10 yr	2.699	0.855–8.520	0.091	1.149	0.574–2.298	0.695
	With PD, > 11 yr	7.156	3.294–15.546	< 0.001	1.032	0.568–1.876	0.917
Adjusted by		Age, gender			Age, gender, all other disorders

All other disorders: alcohol use disorder, eating disorder, obsessive-compulsive disorder, post-traumatic stress disorder, psychotic disorder, bipolar disorder, dysthymic disorder, social phobia, generalized anxiety disorder, specific phobia.

HR = hazard ratio, CI = confidence interval, MDD = major depressive disorder, PD = panic disorder.