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. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: Biochem J. 2019 Jun 25;473(12):1681–1692. doi: 10.1042/BCJ20160069

Fig 1. PI(4,5)P2 metabolism pathways.

Fig 1

(A) Chemical structure of a molecule of phosphatidylinositol and (B) its phosphorylated derivative phosphatidylinositol 4,5-bisphosphate. The phosphate groups at positions 4 and 5 of the head-group are indicated in red. The acyl chains at sn-1 and sn-2 position that are potential sources of structural and functional diversity in this lipid species are marked in green. (C) Schematic showing the enzymatic pathways of PI(4,5)P2 metabolism; enzymes with known roles in the metabolism of this lipid are shown. PI4P: phosphatidylinositol 4 phosphate, PI5P: phosphatidylinostiol 5-phosphate, PI(4,5)P2: phosphatidylinositol 4,5-bisphosphate, DAG: diacylglycerol, Ins(1,4,5)P3: inositol 1,4,5-trisphosphate, PI(3,4,5)P3: phosphatidylinositol 3,4,5-trisphosphate. PIP5K: phosphatidylinostiol 4-phosphate 5 kinase, PIP4K: phosphatidylinositol 5-phosphate 4 kinase, PLC: phospholipase C, Class 1 PI3K: Class I phosphatidylinositol 3 kinase.