Table 3.

Outcomes of acute myeloid leukemia patients with typical and those with atypical complex karyotype

All patients
Endpoint	Atypical CK n=34	Typical CK n=83	P-valuea
Complete remission, n (%)	20 (59)	29 (35)	0.02
Disease-free survival			0.08
Median, years	0.4	0.4
% Disease-free at 1 year (95% CI)	30 (12-50)	3 (0-15)
% Disease-free at 3 years (95% CI)	10 (2-27)	0
Overall survival			<0.001
Median, years	0.8	0.4
% Alive at 1 year (95% CI)	44 (27-60)	14 (8-23)
% Alive at 3 years (95% CI)	24 (11-39)	1 (0-6)
Patients aged <60 years
Endpoint	Atypical CK n=20	Typical CK n=40	P-valuea
Complete remission, n (%)	12 (60)	15 (38)	0.11
Disease-free survival			0.05
Median, years	0.5	0.4
% Disease-free at 1 year (95% CI)	42 (15-67)	0
% Disease-free at 3 years (95% CI)	17 (3-41)	0
Overall survival			0.005
Median, years	0.9	0.6
% Alive at 1 year (95% CI)	45 (23-65)	23 (11-36)
% Alive at 3 years (95% CI)	25 (9-45)	3 (0-11)
Patients aged ≥60 years
Endpoint	Atypical CK n=14	Typical CK n=43	P-valuea
Complete remission, n (%)	8 (57)	14 (33)	0.12
Disease-free survival			0.87
Median, years	0.4	0.3
% Disease-free at 1 year (95% CI)	13 (1-42)	7 (0-28)
% Disease-free at 3 years (95% CI)	0	0
Overall survival			0.002
Median, years	0.8	0.4
% Alive at 1 year (95% CI)	43 (18-66)	7 (2-17)
% Alive at 3 years (95% CI)	21 (5-45)	0

Abbreviations: CK, complex karyotype; CI, confidence interval.

^aP-values for categorical variables are from Fisher’s exact test, P-values for the time to event variables are from the log-rank test.