Skip to main content
. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: J Neurochem. 2008 Apr 1;106(1):24–36. doi: 10.1111/j.1471-4159.2008.05385.x

Fig. 1.

Fig. 1

Electron micrographs of human brain neuromelanin (NM) and lipofuscin (LF). a) NM autophagic vacuoles (AVs) displaying NM (electron dense matrix) and lipid droplets (*) in a substantia nigra dopamine neuron from a 78-year-old subject. Scale bar = 1 μm. The inset shows a 2.4-fold increased magnification of a single NM AV to clearly display a double membrane that delimits this organelle (arrow heads). b) AVs containing NM and lipid droplets (*) in a norepinephrine neuron of the locus coeruleus from a 81-year-old subject. The arrow indicates an expanse where double membrane can be observed indicating that the organelle is an AV. Scale bar = 1 μm. c) LF bodies in a norepinephrine neuron of locus coeruleus of the same subject. Scale bar = 500 nm.