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. 2019 Jan 28;33(7):1635–1649. doi: 10.1038/s41375-018-0368-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mice with Dnmt3a^R878H/+ Npm1^cA/+ AML show expansion of granulocyte-macrophage progenitor cells. a Representative flow cytometric gating for hematopoietic stem and progenitor cells in recipient mice transplanted with Dnmt3a^+/+ Npm1^+/+ or Dnmt3a^R878H/+ Npm1^cA/+ with MDS/MPD, MPD, or AML phenotypes. b Frequency of LT-HSC, ST-HSC, MPP2, and MPP3 and c GMP, CMP, and MEP in donor-derived CD45.2⁺ BM cells (control, n = 2; R878H/+ cA/+ MDS/MPD, n = 2; R878H/+ cA/+ MPD, n = 3; R878H/+cA/+ AML, n = 4). Results are from two independent experiments