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. Author manuscript; available in PMC: 2019 Aug 11.
Published in final edited form as: Lab Invest. 2019 Feb 11;99(7):1041–1048. doi: 10.1038/s41374-019-0233-x

Figure 3.

Figure 3.

Representative immunoblot analysis and quantification of TDP-43, pTDP-43, p62 and OXPHOS key subunits in the soluble protein pool of affected muscle fibers in IBM. Pathogenic pTDP-43 or truncated TDP-43 were significantly increased in the Triton X-100 soluble fraction derived from biopsied muscle fibers from IBM patients, while complex I and III were significantly reduced (n=10 per group). The levels were adjusted by GAPDH. Data are means ± s.e.m. Statistical analysis was done with student t-test. *P < 0.05, **P < 0.01, ns, not significant.