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Representative immunoblot analysis and quantification of TDP-43 and pTDP-43 in the insoluble protein pools of affected muscle fibers in IBM. Pathogenic pTDP-43 or truncated TDP-43 were greatly increased in both SDS and urea solubilized skeletal muscle extracts from Triton X-100 insoluble pellets from IBM patients (n=10 per group). Data are means ± s.e.m. Statistical analysis was done with student t-test. *P < 0.05, **P < 0.01.
