Extended Data Fig. 8. FTY720 treatment has no impact on circulating antibody levels.
C57BL6 mice were infected vaginally with TK− HSV-2. Six weeks later, immunized mice were given drinking water containing 4 μg/ml of FTY720. Two weeks later, FTY720-treated mice were challenged with WT HSV-2 (104 pfu) intravaginally. At the indicated days after challenge, HSV-2-specific antibodies (a) and total antibodies (b) in the blood were measured by ELISA. Sample dilution for virus-specific ELISA was 1:140. Data are mean ± SEM. Data are representative of two independent experiments with 3 mice per group.