Table 2.

Results from polygenic risk score analysis using UK Biobank GWAS summary statistics as discovery and testing aggregate genetic risk between BioVU patients having chart reviewed suicide attempt (left side) and quantitative probability of suicide attempt (right side) using logistic and linear regression, respectively

			Suicide attempt				Predicted risk of suicide attempt
Sample	N	Validated attempt	Est	SE	T	P	Est	SE	T	P
MEGA	18,128	40	22.0	9.2	2.41	0.016	893.7	202.2	4.42	9.96 × 10−6
660	2,965	17	−16.2	31.4	−0.52	0.607	491.7	424.5	1.16	0.247
Omni1M	3,453	16	33.9	24.0	1.41	0.157	44.2	375.9	0.12	0.906
Total	24,546	73	18.39	8.60	2.14	0.033	659.9	164.0	4.02	5.75 × 10−5

Est regression estimate, SE standard error, T regression t-statistic, P p-value