van der Sande 2001.

Methods	Study design: cross‐over RCT Follow‐up period: 4 weeks Duration of study: not reported
Participants	Country: Netherlands Setting: single centre Inclusion criteria: not reported Enrolled: 12 Mean age ± SD: 56.67 ± 15.95 years Sex (M/F): 7/5 Exclusion criteria: not reported
Interventions	Treatment arms Standard temperature HD (37.5°C) Cool‐temperature HD (35.5°C) Postdilution HDF with a low amount of replacement fluid (exchange volume, 1 L/h) with the temperature of 37.5°C HDF with an intermediate amount of replacement fluid (exchange volume, 2.5 L/h) with the temperature of 37.5°C
Outcomes	Maximum decline in MAP Lowest body temperature during dialysis
Notes	Funding source: not reported We requested further information but there was no response
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised; method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Blinding was not feasible because of the nature of the intervention
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement: No description about the first phase data including missing values
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement: The protocol was not available
Other bias	High risk	Carry‐over effects potentially existed. No description for the assessment of the baseline imbalance of first period of the cross‐over study