Table 3. Indicators of liver and kidney function after four weeks of treatment in each group.

Group	n	Time points	ALT (U/l)	AST (U/l)	Cr (µmol/l)	BUN (mmol/l)
Diabetes	30	0 W	29.76 ± 2.67	26.04 ± 2.45	7.96 ± 0.92	126.53 ± 11.97
		4 W	24.26 ± 4.59†	26.89 ± 3.58†	8.97 ± 0.79†	142.61 ± 12.62†
10 mg/(kg·day)	20	0 W	30.25 ± 3.04	25.21 ± 2.38	7.92 ± 0.84	128.29 ± 12.45
		4 W	44.87 ± 4.57†	37.12 ± 3.65†	6.83 ± 0.68†	99.79 ± 11.44†
20 mg/(kg·day)	20	0 W	29.02 ± 3.05	25.63 ± 2.56	7.57 ± 0.79	123.29 ± 11.58
		4 W	45.15 ± 4.52†	37.94 ± 3.83†	6.78 ± 0.73†	95.83 ± 10.56†
40 mg/(kg·day)	20	0 W	31.23 ± 3.16	27.35 ± 2.81	7.79 ± 0.87	120.98 ± 12.15
		4 W	46.08 ± 4.64†	38.26 ± 3.59†	6.63 ± 0.71†	93.52 ± 11.25†
80 mg/(kg·day)	20	0 W	31.78 ± 2.98	26.83 ± 2.69	7.98 ± 0.96	130.27 ± 12.69
		4 W	53.02 ± 5.25*†	48.24 ± 5.02*†	3.01 ± 0.36*†	63.76 ± 7.16*†

Comparison at 0 and 4 W within one group was analyzed by paired t test. Comparison of indicators at different time points was analyzed by repeated measures analysis of variance, followed by Tukey’s post hoc test.

Abbreviations: N, number; W, week.

*P<0.05 versus the diabetes group.

†P<0.05 versus the 0 W.