Table 3. The frequencies of ICOS rs4404254 T>C, rs10932029 T>C, CD28 rs3116496 T>C and CD80 rs7628626 C>A polymorphisms in HCC patients and controls.

Genotype	Overall HCC case (n=584)		Overall controls (n=923)
	n	%	n	%
ICOS rs10932029 T>C
TT	420	73.04	756	82.08
TC	146	25.39	157	17.05
CC	9	1.57	8	0.86
CT+CC	155	26.96	165	17.92
TT+CT	566	98.43	913	99.13
C allele	164	14.26	173	9.39
ICOS rs4404254 T>C
TT	383	66.61	642	69.71
TC	172	29.91	250	27.14
CC	20	3.48	29	3.15
CT+CC	192	33.39	279	30.29
TT+CT	555	96.52	892	96.85
C allele	212	18.43	308	16.72
CD28 rs3116496 T>C
TT	466	81.04	751	81.54
TC	99	17.22	162	17.59
CC	10	1.74	8	0.87
CT+CC	109	18.96	170	18.46
TT+CT	565	98.26	913	99.13
C allele	119	10.35	178	9.66
CD80 rs7628626 C>A
CC	445	77.39	721	78.28
CA	120	20.87	188	20.41
AA	10	1.74	12	1.30
CA+AA	130	22.61	200	21.72
CC+CA	565	98.26	909	98.70
A allele	140	12.17	212	11.51