Table 4. Overall analysis of ICOS rs4404254 T>C, rs10932029 T>C, CD28 rs3116496 T>C and CD80 rs7628626 C>A polymorphisms with HCC.

Genotype	Overall (584 cases vs. 923 controls)
	Crude OR (95% CI)	P	Adjusted OR1 (95% CI)	P
ICOS rs10932029 T>C
Additive model	1.64 (1.27–2.12)	<0.001	1.59 (1.13–2.22)	0.007
Homozygote model	1.99 (0.76–5.19)	0.161	1.12 (0.31–4.03)	0.867
Dominant model	1.69 (1.32–2.17)	<0.001	1.58 (1.14–2.19)	0.007
Recessive model	1.82 (0.76–4.73)	0.223	1.02 (0.28–3.68)	0.974
ICOS rs4404254 T>C
Additive model	1.13 (0.90–1.42)	0.299	0.94 (0.69–1.28)	0.698
Homozygote model	1.13 (0.63–2.03)	0.675	1.21 (0.56–2.61)	0.636
Dominant model	1.15 (0.92–1.44)	0.210	0.98 (0.73–1.31)	0.884
Recessive model	1.11 (0.62–1.98)	0.728	1.24 (0.58–2.66)	0.587
CD28 rs3116496 T>C
Additive model	0.97 (0.74–1.28)	0.821	0.87 (0.60–1.25)	0.437
Homozygote model	1.98 (0.78–5.06)	0.153	1.54 (0.44–5.44)	0.503
Dominant model	1.03 (0.79–1.35)	0.809	0.91 (0.64–1.29)	0.594
Recessive model	2.02 (0.79–5.15)	0.141	1.59 (0.45–5.61)	0.468
CD80 rs7628626 C>A
Additive model	1.02 (0.79–1.32)	0.901	1.00 (0.71–1.40)	0.998
Homozygote model	1.33 (0.57–3.10)	0.513	1.72 (0.57–5.19)	0.332
Dominant model	1.05 (0.82–-1.35)	0.684	1.05 (0.76–1.46)	0.777
Recessive model	1.34 (0.58–3.12)	0.497	1.73 (0.58–5.20)	0.326

¹Adjusted for age, sex, chronic HBV infection, smoking and alcohol use in a logistic regression model.