Table 5. Stratified analyses between ICOS rs10932029 T>C polymorphism and HCC risk.
| Variable | ICOS rs10932029 T>C (case/control)1 | Adjusted OR2 (95% CI); P | ||||||
|---|---|---|---|---|---|---|---|---|
| TT | TC | CC | TT | TC | CC | TC/CC | CC vs. (TC/TT) | |
| Sex | ||||||||
| Male | 379/683 | 129/143 | 9/7 | 1.00 | 1.47 (1.01–2.12); P: 0.043 | 1.56 (0.40–6.18); P: 0.525 | 1.49 (1.04–2.13); P: 0.031 | 1.45 (0.37–5.73); P: 0.595 |
| Female | 41/73 | 17/14 | 0/1 | 1.00 | 2.39 (0.94–6.05); P: 0.067 | - | 2.14 (0.86–5.29); P: 0.101 | - |
| Age (years) | ||||||||
| <53 | 197/319 | 61/72 | 2/2 | 1.00 | 1.41 (0.85–2.35); P: 0.182 | 3.36 (0.34–33.23); P: 0.301 | 1.48 (0.89–2.44); P: 0.128 | 3.15 (0.32–31.09);P: 0.325 |
| ≥53 | 223/437 | 85/85 | 7/6 | 1.00 | 1.70 (1.09–2.64); P: 0.020 | 0.76 (0.18–3.18); P: 0.709 | 1.62 (1.05–2.49); P: 0.029 | 0.69 (0.17–2.85); P: 0.603 |
| Smoking status | ||||||||
| Never | 271/487 | 93/102 | 4/5 | 1.00 | 1.50 (1.00–2.24); P: 0.050 | 0.97 (0.17–5.49); P: 0.973 | 1.49 (1.00–2.22); P: 0.049 | 0.90 (0.16–5.08); P: 0.907 |
| Ever | 149/269 | 53/55 | 5/3 | 1.00 | 1.77 (0.95–3.31); P: 0.072 | 1.33 (0.19–9.37); P: 0.774 | 1.75 (0.95–3.20); P: 0.071 | 1.18 (0.17–8.21); P: 0.866 |
| Alcohol consumption | ||||||||
| Never | 299/635 | 103/132 | 6/6 | 1.00 | 1.56 (1.07–2.26); P: 0.020 | 1.41 (0.34–5.89); P: 0.640 | 1.57 (1.09–2.26); P: 0.016 | 1.30 (0.31–5.41); P: 0.721 |
| Ever | 121/121 | 43/25 | 3/2 | 1.00 | 1.61 (0.76–3.43); P: 0.218 | 0.33 (0.01–8.03); P: 0.497 | 1.50 (0.71–3.16); P: 0.285 | 0.30 (0.01–7.01); P: 0.451 |
| Chronic HBV infection | ||||||||
| Yes | 296/65 | 100/19 | 8/1 | 1.00 | 1.08 (0.60–1.95); P: 0.794 | 1.66 (0.19–14.92); P: 0.650 | 1.14 (0.64–2.03); P: 0.657 | 1.67 (0.19–14.96);P: 0.645 |
| No | 124/691 | 46/138 | 1/7 | 1.00 | 1.85 (1.25–2.73); P: 0.002 | 0.80 (0.10–6.60); P: 0.832 | 1.81 (1.23–2.66); P: 0.003 | 0.70 (0.08–5.79);P: 0.740 |
1
The genotyping was successful in 575 (98.46%) HCC cases and 921 (99.78%) controls for ICOS rs10932029 T>C.
2
Adjusted for age, sex, chronic HBV infection, smoking and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.